Faculty Collaboration Database

Lung cancer inhibitory effect of epigallocatechin-3-gallate is dependent on its presence in a complex mixture (polyphenon E). Cancer Prev Res (Phila) 2009 Jun;2(6):531-7

Date

05/28/2009

Pubmed ID

19470785

DOI

10.1158/1940-6207.CAPR-08-0185

Scopus ID

2-s2.0-68949180099 (requires institutional sign-in at Scopus site)   46 Citations

Abstract

Green tea has been shown to exhibit cancer-preventive activities in preclinical studies. However, (-)-epigallocatechin-3-gallate (EGCG) alone was shown to be ineffective in preventing lung tumorigenesis in mice by aerosol administration. In this study, Polyphenon E and Polyphenon E without EGCG were administered by aerosol delivery to A/J mice 2 weeks after carcinogen treatment and continuing daily throughout the remainder of the study (20 weeks). An improved aerosol delivery system with a custom-built atomizer, an efficient solvent remove system, and a nose-only exposure chamber was used to provide aerosols with stable size distribution. There were no significant differences in the size distributions of Polyphenon E and Polyphenon E without EGCG. With a relatively low dose level (4.19 mg/kg), Polyphenon E decreased tumor multiplicity by 53%, whereas Polyphenon E without EGCG at the same dose failed to inhibit lung carcinogenesis. These results indicate that aerosol administration can be an effective approach in chemoprevention study, and aerosolized Polyphenon E can significantly inhibit pulmonary adenoma formation and growth in A/J mice. Furthermore, in aerosolized form, EGCG, which is thought to be the most active component of Polyphenon E, has to be present with other tea catechins to show chemopreventive activity on lung tumorigenesis.

Author List

Fu H, He J, Mei F, Zhang Q, Hara Y, Ryota S, Lubet RA, Chen R, Chen DR, You M

MESH terms used to index this publication - Major topics in bold

Adenoma
Aerosols
Animals
Anticarcinogenic Agents
Antioxidants
Benzo(a)pyrene
Biological Availability
Catechin
Drug Screening Assays, Antitumor
Drug Synergism
Female
Lung Neoplasms
Mice
Mice, Inbred A
Tea