Advances in the diagnosis and management of persistent pulmonary hypertension of the newborn. Pediatr Clin North Am 2009 Jun;56(3):579-600, Table of Contents
Date
06/09/2009Pubmed ID
19501693Pubmed Central ID
PMC3586568DOI
10.1016/j.pcl.2009.04.004Scopus ID
2-s2.0-67649130036 (requires institutional sign-in at Scopus site) 131 CitationsAbstract
Rapid evaluation of a neonate who is cyanotic and in respiratory distress is essential for achieving a good outcome. Persistent pulmonary hypertension of the newborn (PPHN) can be a primary cause or a contributing factor to respiratory failure, particularly in neonates born at 34 weeks or more of gestation. PPHN represents a failure of normal postnatal adaptation that occurs at birth in the pulmonary circulation. Rapid advances in therapy in recent years have led to a remarkable decrease in mortality for the affected infants. Infants who survive PPHN are at significant risk for long-term hearing and neurodevelopmental impairments, however. This review focuses on the diagnosis, recent advances in management, and recommendations for the long-term follow-up of infants who have PPHN.
Author List
Konduri GG, Kim UOAuthor
Girija Ganesh Konduri MD Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Cardiotonic AgentsContraindications
Extracorporeal Membrane Oxygenation
Humans
Hypnotics and Sedatives
Incidence
Infant, Newborn
Meconium Aspiration Syndrome
Nitric Oxide
Persistent Fetal Circulation Syndrome
Respiratory Therapy
