Effect of aging on the secondary esophageal peristalsis: presbyesophagus revisited. Am J Physiol 1995 May;268(5 Pt 1):G772-9
Date
05/01/1995Pubmed ID
7762661DOI
10.1152/ajpgi.1995.268.5.G772Scopus ID
2-s2.0-0029070564 (requires institutional sign-in at Scopus site) 110 CitationsAbstract
In this study we determined the effect of aging on the capability of the human esophagus to generate secondary peristalsis. We studied nine healthy young (35 +/- 2 yr, 25-45 yr) and nine healthy elderly (74 +/- 3 yr, 70-83 yr) volunteers. We stimulated secondary peristalsis by intraesophageal air injection and balloon distension. All young volunteers exhibited secondary esophageal peristalsis. In four elderly volunteers, secondary peristalsis could not be elicited with injection of any of the tested air volumes. Frequency of stimulation of secondary peristalsis and lower esophageal sphincter (LES) relaxation in response to intraesophageal air distension in the elderly was significantly lower than that in the young (P < 0.01). Stimulation of secondary peristalsis by balloon distension was less consistent compared with the air injection. In conclusion, 1) in the elderly, compared with the young, secondary esophageal peristalsis is either absent or is evoked less frequently after esophageal distension, and complete LES relaxation in response to esophageal air distension is less frequent, and 2) in both young and elderly, secondary esophageal peristalsis is induced more frequently after generalized esophageal distension by air than its segmental distension by a balloon.
Author List
Ren J, Shaker R, Kusano M, Podvrsan B, Metwally N, Dua KS, Sui ZAuthors
Kulwinder S. Dua MD Professor in the Medicine department at Medical College of WisconsinReza Shaker MD Professor in the Medicine department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Aging
Air
Catheterization
Esophagogastric Junction
Esophagus
Humans
Injections
Middle Aged
Peristalsis
Pressure
