Patient-centred screening for primary immunodeficiency, a multi-stage diagnostic protocol designed for non-immunologists: 2011 update. Clin Exp Immunol 2012 Jan;167(1):108-19
Date
12/03/2011Pubmed ID
22132890Pubmed Central ID
PMC3248092DOI
10.1111/j.1365-2249.2011.04461.xScopus ID
2-s2.0-82655184669 (requires institutional sign-in at Scopus site) 155 CitationsAbstract
Members of the European Society for Immunodeficiencies (ESID) and other colleagues have updated the multi-stage expert-opinion-based diagnostic protocol for non-immunologists incorporating newly defined primary immunodeficiency diseases (PIDs). The protocol presented here aims to increase the awareness of PIDs among doctors working in different fields. Prompt identification of PID is important for prognosis, but this may not be an easy task. The protocol therefore starts from the clinical presentation of the patient. Because PIDs may present at all ages, this protocol is aimed at both adult and paediatric physicians. The multi-stage design allows cost-effective screening for PID of the large number of potential cases in the early phases, with more expensive tests reserved for definitive classification in collaboration with a specialist in the field of immunodeficiency at a later stage.
Author List
de Vries E, European Society for Immunodeficiencies (ESID) membersMESH terms used to index this publication - Major topics in bold
AdultAge of Onset
Child
Clinical Protocols
Cytotoxicity Tests, Immunologic
Early Diagnosis
General Practice
Granulocytes
Humans
Immunologic Deficiency Syndromes
Immunophenotyping
Incidence
Lymphocyte Subsets
Mass Screening
Medical History Taking
Patient-Centered Care
Pediatrics
Phenotype
Physical Examination
Recurrence
