Faculty Collaboration Database

Gallium nitrate delays the progression of microscopic disease in a human medulloblastoma murine model. Pediatr Neurol 1994 Jul;11(1):44-6

Date

07/01/1994

Pubmed ID

7986292

DOI

10.1016/0887-8994(94)90089-2

Scopus ID

2-s2.0-0027957135 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

The goal of adjuvant chemotherapy is to treat postoperative microscopic disease in the hope of preventing tumor recurrence and/or metastasis. Since the introduction of chemotherapeutic agents, the disease-free survival of children with medulloblastoma has improved only modestly. Therefore, there is a need to develop and investigate new chemotherapeutic agents for this malignancy. Gallium nitrate has demonstrated significant antineoplastic activity toward human medulloblastoma in vitro and in vivo and may prove to be an optimal chemotherapeutic agent in treating medulloblastoma microscopic disease. The present study consisted of injecting medulloblastoma Daoy intradermally into both flanks of nude mice. A 15-day 50-mg/kg/day regimen was implemented the day after tumor inoculation. All treated and control mice received saline hyperhydration during the treatment period. The interval between tumor cell inoculation and first measurable tumor detection, tumor occurrence, growth rate, and size were recorded. Results indicated that gallium nitrate significantly prolonged the interval between tumor cell inoculation and measurable tumor detection.

Author List

Whelan HT, Williams MB, Bajic DM, Flores RE, Schmidt MH, McAuliffe TL, Chitambar CR

Authors

Christopher Chitambar MBBS Emeritus Professor in the Biophysics department at Medical College of Wisconsin
Timothy L. McAuliffe PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin
Harry Whelan MD Emeritus Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Antineoplastic Agents
Cell Division
Cell Line
Cell Transformation, Neoplastic
Cerebellar Neoplasms
Chemotherapy, Adjuvant
Gallium
Humans
Medulloblastoma
Mice
Mice, Nude
Neoplasm Transplantation