Radiation nephropathy is not mitigated by antagonists of oxidative stress. Radiat Res 2009 Aug;172(2):260-4
Date
07/28/2009Pubmed ID
19630531Pubmed Central ID
PMC2727918DOI
10.1667/RR1739Scopus ID
2-s2.0-70349318558 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
Abstract Persistent, chronic oxidative injury may play a mechanistic role in late radiation injury. Thus antioxidants may be useful as mitigators of radiation injury. The antioxidants deferiprone, genistein and apocynin were tested in a rat radiation nephropathy model that uses single-fraction total-body irradiation (TBI) followed by syngeneic bone marrow transplant. Deferiprone was added to the drinking water at 1.0 or 2.5 g/liter, starting 3 days after the TBI. Urinary bleomycin-detectable iron, which could enhance production of oxygen radicals, was reduced in the rats on deferiprone compared to untreated rats, but deferiprone did not mitigate radiation nephropathy. Genistein added to the chow at 750 mg/kg starting immediately after TBI did not mitigate radiation nephropathy. Apocynin added to the drinking water at 250 mg/liter immediately after TBI did not mitigate radiation nephropathy. Thus three different types of antioxidants, when used at doses consistent with an antioxidant effect, had no mitigation efficacy against radiation nephropathy.
Author List
Cohen EP, Fish BL, Irving AA, Rajapurkar MM, Shah SV, Moulder JEMESH terms used to index this publication - Major topics in bold
AnimalsAntioxidants
Dose-Response Relationship, Radiation
Kidney Diseases
Male
Oxidative Stress
Radiation Dosage
Radiation Injuries
Radiation Tolerance
Radiation-Protective Agents
Rats
Treatment Outcome
Whole-Body Irradiation
