Faculty Collaboration Database

Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat Genet 1996 Jan;12(1):44-51

Date

01/01/1996

Pubmed ID

8528250

DOI

10.1038/ng0196-44

Scopus ID

2-s2.0-0030068479 (requires institutional sign-in at Scopus site)   238 Citations

Abstract

Hypertension, diabetes and hyperlipidemia are risk factors for life-threatening complications such as end-stage renal disease, coronary artery disease and stroke. Why some patients develop complications is unclear, but only susceptibility genes may be involved. To test this notion, we studied crosses involving the fawn-hooded rat, an animal model of hypertension that develops chronic renal failure. Here, we report the localization of two genes, Rf-1 and Rf-2, responsible for about half of the genetic variation in key indices of renal impairment. In addition, we localize a gene, Bpfh-1, responsible for about 26% of the genetic variation in blood pressure. Rf-1 strongly affects the risk of renal impairment, but has no significant effect on blood pressure. Our results show that susceptibility to a complication of hypertension is under at least partially independent genetic control from susceptibility to hypertension itself.

Author List

Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ

MESH terms used to index this publication - Major topics in bold

Animals
Base Sequence
Chromosome Mapping
DNA Primers
Female
Genetic Linkage
Hypertension
Male
Molecular Sequence Data
Proteinuria
Rats
Rats, Inbred Strains
Rats, Mutant Strains
Renal Insufficiency