Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 1996 Jan;12(1):31-7
Date
01/01/1996Pubmed ID
8528247DOI
10.1038/ng0196-31Scopus ID
2-s2.0-0030058877 (requires institutional sign-in at Scopus site) 241 CitationsAbstract
Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases.
Author List
Galli J, Li LS, Glaser A, Ostenson CG, Jiao H, Fakhrai-Rad H, Jacob HJ, Lander ES, Luthman HMESH terms used to index this publication - Major topics in bold
AnimalsBase Sequence
Body Weight
Chromosome Mapping
DNA Primers
Diabetes Mellitus, Type 2
Disease Models, Animal
Fasting
Female
Genetic Linkage
Glucose
Hyperglycemia
Insulin
Male
Molecular Sequence Data
Rats
Rats, Inbred F344
Rats, Mutant Strains
