Acute toxicity of postoperative IMRT and chemotherapy for endometrial cancer. Radiat Med 2007 Nov;25(9):439-45
Date
11/21/2007Pubmed ID
18026901DOI
10.1007/s11604-007-0163-1Scopus ID
2-s2.0-39549094093 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
PURPOSE: The aim of this study was to determine the acute toxicity of postoperative intensity-modulated radiotherapy (IMRT) with and without chemotherapy in patients with endometrial cancer.
MATERIALS AND METHODS: A total of 19 patients with stages IB-IVB endometrial cancer who underwent surgery and postoperative IMRT were reviewed. The treatment planning goal was to cover the tissue at risk and minimize the dose to the bladder, bowel, and bone marrow. Median dose was 50.4 Gy (range 49.6-51.2 Gy). Altogether, 14 patients underwent chemotherapy; most were given carboplatin and paclitaxel. Toxicity was scored according to the Common Terminology Criteria for Adverse Events version 3.0 (CTCAE).
RESULTS: The prescribed radiation treatment was completed in all patients. The prescribed cycles of chemotherapy were completed in all 14 patients, except one who received five of six cycles limited by prolonged thrombocytopenia. Chemotherapy was delayed in two patients (14%). Three patients required growth factor support during chemotherapy, and one patient required a blood transfusion. Acute grades 3-4 hematological toxicity occurred in 9 of the 14 patients (64%) who underwent chemotherapy. None experienced acute grade 3 or 4 genitourinary or gastrointestinal toxicity.
CONCLUSION: Adjuvant IMRT and chemotherapy following surgery in patients with endometrial cancer is well tolerated and did not lead to treatment modification in most patients.
Author List
Tierney RM, Powell MA, Mutch DG, Gibb RK, Rader JS, Grigsby PWAuthor
Janet Sue Rader MD Chair, Professor in the Obstetrics and Gynecology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAntineoplastic Combined Chemotherapy Protocols
Brachytherapy
Carboplatin
Endometrial Neoplasms
Female
Humans
Middle Aged
Neoplasm Staging
Paclitaxel
Radiotherapy Dosage
Radiotherapy, Intensity-Modulated
Treatment Outcome
