Spectral analysis of arterial pressure lability in rats with sinoaortic deafferentation. Am J Physiol 1995 Dec;269(6 Pt 2):R1481-8
Date
12/01/1995Pubmed ID
8594953DOI
10.1152/ajpregu.1995.269.6.R1481Scopus ID
2-s2.0-0029557258 (requires institutional sign-in at Scopus site) 38 CitationsAbstract
Traditionally, the standard deviation (SD) of the mean arterial pressure (AP) has been used as an index for the AP lability produced by interruption of baroreceptor afferents. Although a useful measure of variance about the mean, the SD does not provide any information about the temporal characteristics of this variability. We employed two different spectral analytic techniques to characterize AP waveforms in rats with sinoaortic deafferentation (SAD) and in sham-operated (Sham) rats to determine if the AP waveform in SAD animals was qualitatively and/or quantitatively different from that of Sham animals. The SAD and Sham animals exhibited qualitatively different spectral profiles, suggesting that lability of AP in SAD animals is not simply an exaggeration of normal fluctuations. In addition, a low-frequency (0.3-0.5 Hz) spectral peak was found in Sham but not SAD animals, suggesting that it is associated with the baroreflex. Finally, we observed in both normal rats and rats without intact baroreceptors that the spectral components of AP are not static but rather vary continuously across time.
Author List
Jacob HJ, Ramanthan A, Pan SG, Brody MJ, Myers GAMESH terms used to index this publication - Major topics in bold
Afferent PathwaysAnimals
Blood Pressure
Chlorisondamine
Denervation
Ganglionic Blockers
Male
Models, Cardiovascular
Rats
Rats, Sprague-Dawley
Sinus of Valsalva
