Faculty Collaboration Database

Traumatic hypothermia is related to hypotension, not resuscitation. Ann Emerg Med 1996 Jan;27(1):39-42

Date

01/01/1996

Pubmed ID

8572446

DOI

10.1016/s0196-0644(96)70294-9

Scopus ID

2-s2.0-0030053823 (requires institutional sign-in at Scopus site)   31 Citations

Abstract

STUDY OBJECTIVE: To determine whether posttraumatic hypothermia is associated with hemorrhage or with resuscitation.

METHODS: We used a sequential hemorrhage-resuscitation rat model. Rats were subjected to hemorrhage (30 mL/kg), then 1 hour of shock, followed by 2:1 crystalloid/blood resuscitation (60 mL/kg) at ambient temperature. A control group underwent neither hemorrhage nor resuscitation.

RESULTS: We recorded core temperature and blood pressure every 10 minutes. Temperature drop averaged 3.4 degrees C and was fastest during hypotensive shock. Rate of temperature change correlated with blood pressure (beta = .0102, P < .001), shock phase (beta = .4504, P = .041), and blood pressure during shock phase (beta = .0116, P < .001), but not with resuscitation phase or with duration of shock or resuscitation. Three of 14 rats died during shock, none during resuscitation. An increase in temperature was noted in 1 of 14 rats during shock and in 7 of 11 rats during resuscitation.

CONCLUSION: Hemorrhage-associated hypothermia occurs during hypotensive shock, not during fluid resuscitation.

Author List

Bergstein JM, Slakey DP, Wallace JR, Gottlieb M

MESH terms used to index this publication - Major topics in bold

Animals
Blood Pressure
Body Temperature
Disease Models, Animal
Hypothermia
Linear Models
Male
Rats
Rats, Sprague-Dawley
Resuscitation
Shock, Hemorrhagic
Wounds and Injuries