A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet 1995 Jan;9(1):63-9
Date
01/01/1995Pubmed ID
7704027DOI
10.1038/ng0195-63Scopus ID
2-s2.0-0028894556 (requires institutional sign-in at Scopus site) 462 CitationsAbstract
We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single (SHR x BN) F2 intercross. The loci define 21 large linkage groups corresponding to the 21 rat chromosomes, together with a pair of nearby markers on chromosome 9 that are not linked to the rest of the map. Because 99.5% of the markers fall into one of the 21 large linkage groups, the maps appear to cover the vast majority of the rat genome. The availability of the map should facilitate whole genome scans for genes underlying qualitative and quantitative traits relevant to mammalian physiology and pathobiology.
Author List
Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz T, Lernmark AMESH terms used to index this publication - Major topics in bold
AnimalsBase Sequence
Chromosome Mapping
Crosses, Genetic
DNA Primers
Female
Genetic Linkage
Genetic Markers
Genome
Male
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic
Rats
Rats, Inbred BN
Rats, Inbred SHR
Repetitive Sequences, Nucleic Acid
