Transmural gradient of coronary blood flow following dihydropyridine calcium antagonists and other vasodilator drugs. Basic Res Cardiol 1983;78(6):644-53
Date
11/01/1983Pubmed ID
6661160DOI
10.1007/BF01907211Scopus ID
2-s2.0-0021061222 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
The effects of the dihydropyridine calcium antagonists, nifedipine, nitrendipine and FR 7534 on the transmural distribution of coronary blood flow (endo/epi) were compared to the structurally unrelated calcium antagonists, verapamil and diltiazem and to the non-calcium antagonist vasodilator drugs, chromonar and dipyridamole in anesthetized dogs. The increase in transmural blood flow produced by diltiazem, verapamil, chromonar and dipyridamole was equally distributed between subendocardium and subepicardium (no change in endo/epi). On the other hand, the increase in myocardial blood flow produced by the dihydropyridine calcium antagonists nifedipine, nitrendipine and FR 7534 was relatively selective for subepicardial regions resulting in a significant and dose-related decrease in endo/epi. This unusual effect of the dihydropyridine calcium antagonists to produce a redistribution of flow within normal myocardium was not shared by the non-dihydropyridine calcium antagonists or non-calcium antagonist vasodilators studied. The redistribution of flow was not related to changes in heart rate, aortic blood pressure or to the level of total coronary blood flow. Such an effect may be related to the distribution of dihydropyridine receptors across the left ventricular wall, antagonism of the action of adenosine, or changes in regional intramyocardial tissue pressure and extravascular resistance.
Author List
Warltier DC, Hardman HF, Brooks HL, Gross GJMESH terms used to index this publication - Major topics in bold
AnimalsBlood Flow Velocity
Chromonar
Coronary Circulation
Diltiazem
Dipyridamole
Dogs
Female
Hemodynamics
Male
Nifedipine
Nitrendipine
Vasodilator Agents
Verapamil
