Coronary hemodynamics and subendocardial perfusion distal to stenoses. Int J Cardiol 1983 Sep;4(2):173-83
Date
09/01/1983Pubmed ID
6629531DOI
10.1016/0167-5273(83)90131-6Scopus ID
2-s2.0-0020618290 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
We compared distal coronary hemodynamics and regional myocardial perfusion in anesthetized dogs in the presence of a single or two coronary artery stenoses in series. After application of either a single or two stenoses on the left anterior descending coronary artery, regional myocardial blood flow was measured with radioactive microspheres. Moderate degrees of single-vessel stenosis (no change in resting coronary blood flow but reduction in reactive hyperemic response of 70%) resulted in no significant change in regional myocardial perfusion at rest despite a pressure drop across the stenosis of 24 +/- 3 mm Hg. When two such stenoses were applied in series, there was a 91% decrease in reactive hyperemia, a significant reduction in resting diastolic coronary blood flow and a 51 +/- 7 mm Hg pressure drop across the two stenoses. Alone, each stenosis produced no change in regional myocardial perfusion; however, together the two stenoses resulted in a significant decrease in subendocardial blood flow and a redistribution of transmural perfusion within the ischemic zone favoring the subepicardium (endo/epi from 0.95 +/- 0.03 to 0.72 +/- 0.03). The results indicate that whereas resting subendocardial perfusion is not significantly affected by moderate degrees of a single coronary artery stenosis, multiple stenoses of the same severity may dramatically reduce subendocardial perfusion.
Author List
Warltier DC, Buck JD, Brooks HL, Gross GJMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Coronary Circulation
Coronary Disease
Coronary Vessels
Dogs
Female
Heart
Heart Rate
Hemodynamics
Male
Microspheres
Myocardial Contraction
Radioisotopes
Radionuclide Imaging
