Faculty Collaboration Database

The effect of diltiazem, a calcium channel blocking agent, on vasoconstrictor responses to norepinephrine, serotonin and potassium depolarization in canine coronary and femoral arteries. Gen Pharmacol 1983;14(2):259-64

Date

01/01/1983

Pubmed ID

6840509

DOI

10.1016/0306-3623(83)90006-x

Scopus ID

2-s2.0-0020700973 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

1. Diltiazem produced a dose-dependent inhibition of contractions due to norepinephrine (NE), serotonin (5HT) and high potassium depolarization in both coronary and femoral artery rings. 2. Diltiazem was a more potent and efficacious blocker of all 3 agonists in the coronary arteries. 3. Dose response curves to NE and 5HT indicated that diltiazem produced a noncompetitive type of blockade. 4. Diltiazem blocked contractions produced by 5HT more easily than those produced by NE in both coronary and femoral artery rings. 5. That diltiazem was more potent in coronary than femoral arteries suggests a basic difference in calcium regulation in the two vessels.

Author List

Mullett M, Gharaibeh M, Warltier DC, Gross GJ

MESH terms used to index this publication - Major topics in bold

Animals
Benzazepines
Calcium Channel Blockers
Coronary Vessels
Diltiazem
Dogs
Dose-Response Relationship, Drug
Femoral Artery
In Vitro Techniques
Muscle, Smooth, Vascular
Norepinephrine
Potassium
Serotonin
Time Factors
Vasoconstriction