Importance of retrograde coronary flow in the prediction of experimental myocardial infarct size. Cardiology 1986;73(6):333-46
Date
01/01/1986Pubmed ID
3791333DOI
10.1159/000174027Scopus ID
2-s2.0-0023035460 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
The relationship between myocardial infarct size (measured by a histochemical stain) and coronary collateral blood flow (measured via retrograde flow and by use of radioactive microspheres) was studied in anesthetized dogs with high, moderate and low retrograde flows undergoing a 2-hour occlusion and 30-min reperfusion of the left anterior descending coronary artery. The results demonstrate that experimental myocardial infarct size is closely related to native coronary collateral blood flow, and the large variability in collateral perfusion amongst dogs is a source of variability in the mass of myocardium undergoing irreversible damage following acute coronary occlusion. Results also demonstrate that the variability in experimental infarct size can be reduced and ultimate infarct size predicted prior to irreversible tissue injury by initial measurement of retrograde coronary blood flow.
Author List
Warltier DC, Zyvoloski MG, Gross GJ, Brooks HLMESH terms used to index this publication - Major topics in bold
AnimalsBlood Flow Velocity
Blood Pressure
Collateral Circulation
Coronary Circulation
Coronary Disease
Dogs
Heart
Hemodynamics
Myocardial Infarction
Predictive Value of Tests
Radionuclide Imaging
Risk
