Beneficial effects of the dihydropyridine calcium antagonist, FR 34235, in a chronic coronary occlusion model. Eur J Pharmacol 1982 May 07;80(1):149-53
Date
05/07/1982Pubmed ID
7095001DOI
10.1016/0014-2999(82)90192-3Scopus ID
2-s2.0-0020060513 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
Administration of FR 34235 reduced aortic blood pressure and increased cardiac output in anesthetized dogs with an ameroid-induced coronary artery occlusion. Following FR 34235, there was an increase in perfusion within normal myocardium and ischemic subepicardium. Ischemic zone flow to subepicardium and subendocardium were both significantly increased when aortic pressure was held at control levels. The data demonstrate marked enhancement in oxygen supply to an area distal to a chronic coronary occlusion by a new calcium antagonist, FR 34235.
Author List
Warltier DC, Zyvoloski MG, Brooks HL, Gross GJMESH terms used to index this publication - Major topics in bold
AnimalsCalcium Channel Blockers
Coronary Circulation
Coronary Disease
Dogs
Hemodynamics
Nifedipine
Pyridines
