Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc Natl Acad Sci U S A 1994 Aug 02;91(16):7598-602
Date
08/02/1994Pubmed ID
8052626Pubmed Central ID
PMC44449DOI
10.1073/pnas.91.16.7598Scopus ID
2-s2.0-0028031296 (requires institutional sign-in at Scopus site) 326 CitationsAbstract
The expression of HNF-4 (hepatocyte nuclear factor 4) mRNA in postimplantation mouse embryos was analyzed by in situ hybridization. Expression was found in the primary endoderm at embryonic day 4.5 and was restricted to the columnar visceral endoderm cells of the yolk sac from day 5.5 to day 8.5. HNF-4 mRNA was first detected in embryonic tissues at day 8.5, in the liver diverticulum and the hindgut. At later times HNF-4 transcripts were observed in the mesonephric tubules, pancreas, stomach, and intestine and, still later, in the metanephric tubules of the developing kidney. This expression pattern suggests that HNF-4 has a role in the earliest stages of murine postimplantation development as well as in organogenesis.
Author List
Duncan SA, Manova K, Chen WS, Hoodless P, Weinstein DC, Bachvarova RF, Darnell JE JrMESH terms used to index this publication - Major topics in bold
AnimalsBase Sequence
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
DNA-Binding Proteins
Digestive System
Endoderm
Genes, Reporter
Hepatocyte Nuclear Factor 4
In Situ Hybridization
Kidney
Liver
Mice
Molecular Sequence Data
Phosphoproteins
Recombinant Fusion Proteins
Transcription Factors
