Immunoregulation in hypersensitivity pneumonitis: phenotypic and functional studies of bronchoalveolar lavage lymphocytes. Am Rev Respir Dis 1984 Nov;130(5):766-71
Date
11/01/1984Pubmed ID
6208833DOI
10.1164/arrd.1984.130.5.766Scopus ID
2-s2.0-0021715964 (requires institutional sign-in at Scopus site) 41 CitationsAbstract
We examined the immunologic phenotype and function of bronchoalveolar lymphocytes isolated from 4 pigeon breeders who developed symptoms of hypersensitivity pneumonitis on exposure to pigeons, and 6 asymptomatic but equally exposed individuals. Similar numbers of bronchoalveolar lymphocytes were found in symptomatic breeders compared with the asymptomatic, and the percent of T11, T4, and T8 bearing cells as well as the T4/T8 ratios were similar in both groups. Despite these similarities, the groups had significantly different functional activity. Bronchoalveolar lymphocytes from symptomatic breeders demonstrated a marked (p less than 0.001) increase in blastogenic activity to both phytohemagglutinin and pigeon serum stimulation when compared with asymptomatic breeders. In addition, enriched bronchoalveolar T-cells suppressed the response of autologous preincubated peripheral blood lymphocytes to both phytohemagglutinin and pigeon serum in the asymptomatic compared with the symptomatic breeders. These studies suggest a discrepancy between the phenotype and function of immunoregulatory T-cell subsets in bronchoalveolar lavage lymphocytes in pigeon breeder's disease, and support a role for functional immunoregulatory imbalances in the pathogenesis of hypersensitivity pneumonitis.
Author List
Keller RH, Swartz S, Schlueter DP, Bar-Sela S, Fink JNMESH terms used to index this publication - Major topics in bold
AdultAlveolitis, Extrinsic Allergic
Animals
Antigens, Surface
Bird Fancier's Lung
Bronchi
Cells, Cultured
Columbidae
Epitopes
Humans
Lymphocyte Activation
Male
Middle Aged
Phenotype
Phytohemagglutinins
Pulmonary Alveoli
Smoking
T-Lymphocytes
