Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance ability. Hippocampus 2010 Mar;20(3):345-51
Date
01/21/2010Pubmed ID
20087893Pubmed Central ID
PMC2872925DOI
10.1002/hipo.20771Scopus ID
2-s2.0-77649142619 (requires institutional sign-in at Scopus site) 78 CitationsAbstract
When given challenging episodic memory tasks, young adults demonstrate notable individual differences in performance. Recent evidence suggests that individual differences in human behavior may be related to the strength of functional connectivity of large-scale functional networks as measured by spontaneous fluctuations in regional brain activity during quiet wakefulness (the "resting state"), in the absence of task performance. In this study, we sought to determine whether individual differences in memory performance could be predicted by the interhemispheric functional connectivity of the two hippocampi, hypothesized to reflect the intrinsic connectivity within the large-scale medial temporal lobe memory system. Results demonstrated that interhemispheric hippocampal functional connectivity during quiet wakefulness was predictive of the capacity to freely recall recently learned information (r = 0.47, P < 0.05). In contrast, functional connectivity of bilateral motor cortices had no relationship to free recall, supporting the specificity of the hippocampal data. Thus, individual differences in the capacity to perform episodic memory tasks, which may be persistent behavioral traits or transient states, may be at least partly subserved by individual differences in the functional connectivity of large-scale functional-anatomic memory networks.
Author List
Wang L, Negreira A, LaViolette P, Bakkour A, Sperling RA, Dickerson BCAuthor
Peter LaViolette PhD Vice Chair, Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Brain MappingFunctional Laterality
Hippocampus
Learning
Magnetic Resonance Imaging
Memory
Mental Recall
Neural Pathways
Neuropsychological Tests
Observer Variation
Task Performance and Analysis
Wakefulness
