Effects of bradycardic agents on ischaemic myocardium and perfusion in anesthetized dogs. Eur Heart J 1987 Dec;8 Suppl L:69-74
Date
12/01/1987Pubmed ID
3451885DOI
10.1093/eurheartj/8.suppl_l.69Scopus ID
2-s2.0-0023609015 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
The effects of several new specific bradycardic agents, AQ-A39 and AQ-AH 208, were evaluated in two models of myocardial ischaemia in anesthetized dogs. In the first model, equal bradycardic doses of AQ-AH 208 and propranolol were compared for their effects on coronary collateral blood flow in dogs subjected to an acute coronary artery occlusion. AQ-AH 208 produced a significant (P less than 0.05) increase (35%) in transmural collateral perfusion whereas propranolol had no effect. Atrial pacing to control heart rate only partially negated the beneficial effect of AQ-AH 208 on collateral flow. In the second model of ischaemia, AQ-AH 208 and AQ-A39 were evaluated for their effects on subendocardial segment shortening (% SS) and regional myocardial blood flow in dogs subjected to 15 minutes of coronary artery occlusion, followed by 3 hours of reperfusion. Both compounds produced similar decreases in heart rate (24%) and increases in the endocardial/epicardial distribution of collateral blood flow. During occlusion and throughout reperfusion, AQ-AH 208 and AQ-A39 resulted in a significant improvement in % SS in the ischaemic-reperfused region. These results suggest that specific bradycardic agents may have potential for therapeutic use in certain types of myocardial ischaemia by several different mechanisms.
Author List
Gross GJ, Daemmgen JWMESH terms used to index this publication - Major topics in bold
Anesthesia, GeneralAnimals
Anti-Arrhythmia Agents
Collateral Circulation
Coronary Circulation
Coronary Disease
Dogs
Female
Isoindoles
Male
Phthalimides
Propranolol
