Coagulopathy of disseminated neuroblastoma. J Pediatr 1983 Aug;103(2):219-22
Date
08/01/1983Pubmed ID
6875712DOI
10.1016/s0022-3476(83)80348-5Scopus ID
2-s2.0-0020589391 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
We performed coagulation studies in 16 patients with advanced neuroblastoma. Four of these patients had major hemorrhagic or thromboembolic complications. Abnormal coagulation screening tests were seen in all patients with active metastatic disease. We also measured plasma fibrinopeptide A, a sensitive measure of intravascular thrombin generation. Increased concentrations of fibrinopeptide A were found in each patient studied with active metastatic disease. Coagulopathy is a frequent finding in metastatic neuroblastoma and may cause severe morbidity. Laboratory studies suggesting either hyper- or hypocoagulability are frequent findings.
Author List
Scott JP, Morgan EMESH terms used to index this publication - Major topics in bold
Blood Coagulation FactorsChild, Preschool
Disseminated Intravascular Coagulation
Fibrin Fibrinogen Degradation Products
Fibrinopeptide A
Humans
Infant
Male
Neuroblastoma
Partial Thromboplastin Time
Prothrombin Time
