Intrapulmonary growth and dissemination of an avirulent strain of Cryptococcus neoformans in mice depleted of CD4+ or CD8+ T cells. J Exp Med 1991 Mar 01;173(3):755-8
Date
03/01/1991Pubmed ID
1900084Pubmed Central ID
PMC2118808DOI
10.1084/jem.173.3.755Scopus ID
2-s2.0-0026036129 (requires institutional sign-in at Scopus site) 116 CitationsAbstract
The contribution of T lymphocyte subpopulations to intrapulmonary and systemic resistance against an opportunistic strain of Cryptococcus neoformans was examined. It was found that C. neoformans was destroyed when introduced into the lungs of normal mice, but disseminated to the brains of mice treated with an antibody that depleted them of CD4+ T cells. Depletion of either CD8+ or CD4+ T cells impaired the ability of the host to clear the yeast from the lung. These results, together with the observation that CD8+ T cells accumulate in the lungs of CD4+ T cell-deficient mice, suggest that CD8+ T cells play an important role in resistance to C. neoformans infection acquired via the respiratory tract.
Author List
Hill JO, Harmsen AGMESH terms used to index this publication - Major topics in bold
AnimalsAntibodies, Monoclonal
Antigens, Differentiation, T-Lymphocyte
CD4 Antigens
CD8 Antigens
Cryptococcosis
Cryptococcus neoformans
Lung
Lymphocyte Depletion
Mice
Mice, Inbred BALB C
T-Lymphocyte Subsets
T-Lymphocytes
