Aspergillus fumigatus peptides differentially express Th1 and Th2 cytokines. Peptides 1996;17(2):183-90
Date
01/01/1996Pubmed ID
8801519DOI
10.1016/0196-9781(95)02104-3Scopus ID
2-s2.0-0029886383 (requires institutional sign-in at Scopus site) 42 CitationsAbstract
Relevant allergens from Aspergillus fumigatus associated with allergic bronchopulmonary aspergillosis (ABPA) have been cloned and expressed. The pathogenesis of ABPA probably depends on specific cytokines and immunoglobulins secreted by lymphocytes on stimulation with different epitopes of those allergens. In the present study, we synthesized peptides of 12-16 amino acids from the sequence of Asp fI and compared their immunological responses in four mice strains (BALB/c, C57BL/6, AKR, and CBA). Of the five peptides studied for their cytokine profile, one showed a clear Th1, whereas another showed a Th2 response. The remaining three peptides varied in their immunoreactivity. The results suggest that a number of epitopes of diverse activities are present in individual molecules and may be involved in the pathogenesis of ABPA through differential cytokine secretions.
Author List
Kurup VP, Hari V, Guo J, Murali PS, Resnick A, Krishnan M, Fink JNMESH terms used to index this publication - Major topics in bold
AllergensAmino Acid Sequence
Animals
Antibodies, Fungal
Antigens, Plant
Aspergillus fumigatus
Cytokines
Fungal Proteins
Immunoglobulin A
Interferon-gamma
Interleukin-10
Interleukin-2
Interleukin-4
Interleukin-5
Mice
Mice, Inbred AKR
Mice, Inbred BALB C
Mice, Inbred C57BL
Molecular Sequence Data
Ribonucleases
Th1 Cells
Th2 Cells
