Faculty Collaboration Database

Role of adenosine receptor subtypes in neural stunning of sympathetic coronary innervation. Am J Physiol 1997 Jan;272(1 Pt 2):H25-34

Date

01/01/1997

Pubmed ID

9038919

DOI

10.1152/ajpheart.1997.272.1.H25

Scopus ID

2-s2.0-0031025450 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

Adenosine plays an important role in postischemic dysfunction of cardiac sympathetic nerves because exogenously infused adenosine produces and adenosine deaminase prevents "neural stunning." We examined whether adenosine acts via a specific receptor mechanism to produce neural stunning. Anesthetized dogs were treated with propranolol to attenuate increases in coronary flow due to adrenergic stimulation of myocardial metabolism. A 15-min occlusion of the left anterior descending coronary artery (LAD) attenuated subsequent LAD coronary vasoconstriction to bilateral sympathetic stimulation during reperfusion by 75% (P < 0.05). Coronary infusion of the adenosine-receptor antagonist 8-p-sulfophenyltheophylline (nonspecific), 8-cyclopentyl-1,3-dipropylxanthine (A1 specific), or 3,7-dimethyl-1-propagylxanthine (A2 specific) during LAD occlusion prevented the attenuation of sympathetic coronary constriction. In separate experiments, either the specific adenosine agonist N6-cyclopentyl-adenosine (A1 specific) or CGS-21680 (A2 specific) or a combination of both agonists was infused into the LAD for 15 min. Neither agonist alone attenuated subsequent sympathetic coronary constriction. In contrast, 15 min after the combined administration of both agonists, sympathetic vasoconstriction was reduced. We conclude that adenosine is capable of attenuating neurogenic coronary constriction through a receptor-mediated mechanism. Activation of more than one receptor subtype is necessary to produce neural stunning.

Author List

Abe T, Morgan DA, Gutterman DD

MESH terms used to index this publication - Major topics in bold

Adenosine
Animals
Coronary Vessels
Dogs
Female
Male
Myocardial Stunning
Phenethylamines
Purinergic P1 Receptor Agonists
Purinergic P1 Receptor Antagonists
Receptors, Purinergic P1
Sympathetic Nervous System
Theobromine
Theophylline
Vasoconstriction
Xanthines