Faculty Collaboration Database

Relationship of severity of myocardial stunning to ATP dependent potassium channel modulation. J Card Surg 1993 Mar;8(2 Suppl):279-83

Date

03/01/1993

Pubmed ID

8461517

DOI

10.1111/j.1540-8191.1993.tb01323.x

Scopus ID

2-s2.0-0027523308 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

Pharmacological modulation of ATP sensitive potassium channels (K+ATP channels) in vivo may influence ischemia and reperfusion injury of myocardium. The purpose of this investigation was to ascertain the actions of multiple K+ATP channel openers and interactions with a K+ATP channel antagonist in a model of stunned myocardium in anesthetized and conscious dogs. The results indicate that the K+ATP channel openers, aprikalim and nicorandil, enhance recovery of regional contractile function of stunned myocardium. This action was blocked by the selective K+ATP antagonist, glyburide. The beneficial effects of K+ATP channel openers were not related to changes in systemic hemodynamics or coronary collateral perfusion, but instead may be a manifestation of direct cardioprotective actions of these compounds.

Author List

Warltier DC, Auchampach JA, Gross GJ

Author

John A. Auchampach PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adenosine Triphosphate
Animals
Coronary Circulation
Dogs
Glyburide
Myocardial Contraction
Myocardial Ischemia
Myocardial Reperfusion Injury
Niacinamide
Nicorandil
Potassium Channels
Vasodilator Agents