Hyperprolactinemia--a review of recent clinical advances. Arch Intern Med 1979 Dec;139(12):1415-9
Date
12/01/1979Pubmed ID
518224Scopus ID
2-s2.0-0018601810 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
Since the radioimmunoassay for serum prolactin became available eight years ago, prolactin has become a hormone of considerable clinical interest. An elevated serum prolactin concentration is the most frequent hormone marker for pituitary tumors. Secreted in excess, prolactin causes dysfunction of the hypothalamic-pituitary axis, the gonads, and the adrenal cortex. In women, menstrual disturbances, galactorrhea, infertility, and hirsutism result. Impotence, oligospermia, and decreased libido are common in men. These metabolic abnormalities attributed to prolactin excess are corrected when prolactin concentrations are lowered by either medical or surgical therapy. The availability of effective therapy mandates early recognition and proper management of the patient with hyperprolactinemia.
Author List
Kirby RW, Kotchen TA, Rees EDMESH terms used to index this publication - Major topics in bold
BromocriptineDopamine
Erectile Dysfunction
Estradiol
Female
Follicle Stimulating Hormone
Humans
Hypothalamo-Hypophyseal System
Luteinizing Hormone
Male
Menstruation Disturbances
Myxedema
Pituitary Diseases
Pregnancy
Prolactin
