Importance of chloride for acute inhibition of renin by sodium chloride. Am J Physiol 1978 Nov;235(5):F444-50
Date
11/01/1978Pubmed ID
31796DOI
10.1152/ajprenal.1978.235.5.F444Scopus ID
2-s2.0-0018039423 (requires institutional sign-in at Scopus site) 58 CitationsAbstract
To evaluate the contribution of chloride to acute renin inhibition by sodium chloride, plasma renin activity (PRA) was measured before and after peripheral venous infusion of NaCl, NaHCO3, NaBr, NaNO3, lysine monohydrochloride, or lysine glutamate in NaCl-deprived rats. In contrast to controls and animals infused with other sodium salts, PRA decreased (P less than 0.01) after infusion with NaCl [from 28.3 +/- 2.8 to 13.3 +/- 1.8 ng/ml per h (SE)] and NaBr (from 40.6 +/- 6.2 to 21.8 +/- 3.9 ng/ml per h), and renal tubular halide reabsorption increased (P less than 0.05). Arterial pressure, plasma volume, inulin clearance, net sodium balance, serum Na+ and K+, and pH were not different among sodium-loaded groups. PRA was also suppressed (P less than 0.01) by infusion with lysine monohydrochloride (from 51.6 +/- 5.4 to 32.4 +/- 5.1 ng/ml per h) but not with lysine glutamate. These results suggest that inhibition of renin by sodium is dependent on an intrarenal effect of chloride. During infusion with sodium salts which suppressed renin, negative free water clearance (TcH2O) increased, whereas infusion with sodium salts that did not inhibit renin resulted in either no change or decreased TcH2O. The association of renin inhibition and increased TcH2O indirectly supports the hypothesis that renin suppression by chloride is related to the magnitude of absorptive chloride transport in the thick ascending limb of the loop of Henle.
Author List
Kirchner KA, Kotchen TA, Galla JH, Luke RGMESH terms used to index this publication - Major topics in bold
Amino AcidsAnimals
Blood Pressure
Blood Volume
Chlorides
Diuresis
Glomerular Filtration Rate
Hydrogen-Ion Concentration
Male
Natriuresis
Rats
Renin
Sodium Chloride
Water-Electrolyte Balance
