Faculty Collaboration Database

Failure of NaHCO3 and KHCO3 to inhibit renin in the rat. Am J Physiol 1976 Oct;231(4):1050-6

Date

10/01/1976

Pubmed ID

984192

DOI

10.1152/ajplegacy.1976.231.4.1050

Scopus ID

2-s2.0-0017103824 (requires institutional sign-in at Scopus site)   40 Citations

Abstract

To evaluate the contribution of chloride to NaCl- and KCl-induced renin inhibition, renin responses to NaCl or NaHCO3 and to KCl or KHCO3 loading were compared in NaCl-deprived rats. Sodium balance in animals drinking isotonic NaHCO3 and NaCl for 9 days did not differ (P greater than 0.40); K+ balance was less positive in NaHCO3-drinking animals (P less than 0.005). Plasma renin activity (PRA) in NaCl-loaded (16.5 ng/ml per h +/- 4.4 SE), but not in NaHCO3-loaded rats (57.2 +/- 9.8), was lower (P less than 0.005) than in NaCl-deprived controls (44.8 +/- 4.7). Renal renin content (RRC) of NaCl but not of NaHCO3-drinking animals was also decreased (P less than 0.02). Both PRA and RRC of KCl- but not of KHCO3-loaded rats (5 meq K+/10 g diet) were lower (P less than 0.01) than in NaCl-deprived controls. After acute intravenous expansion with isotonic NaCl or NaHCO3, increases of plasma volume and plasma K+ did not differ (P greater than 0.05). However, PRA of NaCl-expanded rats (11.8 +/- 3.8) was lower (P less than 0.05) than in NaHCO3-expanded animals (29.7 +/- 8.5). The failure of NaHCO3 and KHCO3 to inhibit renin suggests a role for chloride in mediating the renin responses to Na+ and K+.

Author List

Kotchen TA, Galla JH, Luke RG

MESH terms used to index this publication - Major topics in bold

Acid-Base Equilibrium
Animals
Bicarbonates
Biological Transport, Active
Kidney
Male
Potassium
Potassium Chloride
Rats
Renin
Sodium
Sodium Chloride