Faculty Collaboration Database

Pharmacologic- vs. ischemia-induced coronary artery vasodilation. Am J Physiol 1981 May;240(5):H767-74

Date

05/01/1981

Pubmed ID

7235035

DOI

10.1152/ajpheart.1981.240.5.H767

Scopus ID

2-s2.0-0019568288 (requires institutional sign-in at Scopus site)   53 Citations

Abstract

Responses of total coronary and regional myocardial blood flow to ischemia- or drug-induced coronary artery vasodilation were studied in open-chest anesthetized dogs. Systolic, diastolic, and mean coronary blood flow after addition of chromonar (8 mg/kg iv), adenosine triphosphate (400 micrograms/min intracoronary), or adenosine (500 micrograms/min intracoronary) exceeded the respective flow at the peak of reactive hyperemia (90-s occlusion period). Whereas the regional distribution of total coronary flow favored the subendocardium of the left ventricle during reactive hyperemia, flow was preferentially distributed to subepicardium during drug-induced maximal coronary artery vasodilation. These results were independent of type of anesthesia, vasodilator agent, or degree of autonomic innervation. These data indicate that total coronary vasodilator reserve is greater than that observed at the peak of reactive hyperemia and that there is a transmural gradient of vasodilator reserve within the left ventricle. A greater regional vasodilator reserve is present in subepicardial than in subendocardial layers.

Author List

Warltier DC, Gross GJ, Brooks HL

MESH terms used to index this publication - Major topics in bold

Adenosine
Adenosine Triphosphate
Animals
Chromonar
Coronary Disease
Coronary Vessels
Dogs
Female
Hemodynamics
Hyperemia
Male
Vasodilation