Faculty Collaboration Database

Adenosine on myocardial oxygen consumption. Br J Pharmacol 1976 Jul;57(3):409-12

Date

07/01/1976

Pubmed ID

974320

Pubmed Central ID

PMC1667219

DOI

10.1111/j.1476-5381.1976.tb07681.x

Scopus ID

2-s2.0-0017080913 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

1 A 3 min intracoronary infusion of adenosine (50 mug/min) produced a significant decrease in coronary artery perfusion pressure, left ventricular systolic pressure and myocardial O2 consumption in the isolated supported heart preparation of the dog perfused at a constant coronary blood flow. Heart rate was controlled at 150, 190 or 230 beats/minute. 2 Myocardial contractile force and maximal left ventricular dp/dt were not changed by adenosine infusion. 3 The absolute decrease in myocardial O2 consumption was greater at increasing heart rates whereas the decrease in coronary artery perfusion pressure and peak left ventricular systolic pressure were similar. 4 The results suggest that the reduction in myocardial O2 consumption produced by adenosine is not related to coronary vasodilatation or to a negative chronotropic or inotropic action, but may be due to a functional shunting of blood flow from high O2 extracting regions of the myocardium to low O2 extracting ones and/or important effects on myocardial substrate utilization.

Author List

Gross GJ, Hardman HF, Warltier DC

MESH terms used to index this publication - Major topics in bold

Adenosine
Animals
Blood Pressure
Coronary Circulation
Depression, Chemical
Dogs
Heart
Heart Rate
Myocardial Contraction
Myocardium
Oxygen Consumption