Faculty Collaboration Database

In-vivo generation of leukaemia-derived dendritic cells. Best Pract Res Clin Haematol 2004 Sep;17(3):439-51

Date

10/23/2004

Pubmed ID

15498715

DOI

10.1016/j.beha.2004.06.004

Scopus ID

2-s2.0-7744226324 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

Adoptive immunotherapy with transfusion of donor lymphocytes in allogeneic stem cell chimeras has been successful in the treatment of recurrent chronic myelogenous leukaemia (CML) and some patients with acute myeloid leukaemia (AML). The hypothesis that the graft-vs-leukaemia effect (GVL) is promoted by leukaemia-derived dendritic cells has been supported by the concurrent treatment of patients with cytokines that are known to induce differentiation of leukaemia cells towards dendritic cells. In combination with donor lymphocyte transfusions, treatment with interferon-alpha and granulocyte-macrophage colony-stimulating factor has been studied in patients with recurrent CML and AML, and pre-emptively in patients with high-risk AML. Long-term remissions have been observed in cytokine-treated patients, indicating the beneficial effect of cytokine stimulation of GVL reactions. This is likely to be due to differentiation of leukaemia progenitor cells towards dendritic cells in vivo.

Author List

Kolb HJ, Rank A, Chen X, Woiciechowsky A, Roskrow M, Schmid C, Tischer J, Ledderose G

Author

Xiao Chen MD, PhD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Cell Lineage
Dendritic Cells
Graft vs Leukemia Effect
Humans
Immunotherapy, Adoptive
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Neoplastic Stem Cells