Faculty Collaboration Database

Protective role of nerve growth factor against postischemic dysfunction of sympathetic coronary innervation. Circulation 1997 Jan 07;95(1):213-20

Date

01/07/1997

Pubmed ID

8994439

DOI

10.1161/01.cir.95.1.213

Scopus ID

2-s2.0-0031014833 (requires institutional sign-in at Scopus site)   80 Citations

Abstract

BACKGROUND: Nerve growth factor (NGF) is produced rapidly in myocardium after brief myocardial ischemia. It contributes to the maintenance of neural integrity in several tissues. We examined the effect of exogenous and endogenous NGF on ischemia-induced dysfunction of cardiac sympathetic nerves.

METHODS AND RESULTS: In anesthetized dogs, bilateral stellate stimulation was performed, measuring changes in coronary vascular resistance (% delta CVR) before and after release of either a 7- or 15-minute occlusion of the left anterior descending coronary artery (LAD). NGF (10 ng.kg-1.min-1, n = 5) or vehicle (n = 6) was infused into the LAD in dogs during a 15-minute LAD occlusion. In separate experiments, antibody to NGF (anti-NGF, 2 ng.kg-1.min-1, n = 5) or vehicle (n = 6) was infused into dogs during a 7-minute LAD occlusion. After release of a 15-minute LAD occlusion, attenuation of the coronary constriction to stellate stimulation was seen in the vehicle group (30 +/- 3% to 15 +/- 1% increase in CVR, P < .05); however, no such reduction was seen in the group receiving NGF. A 7-minute LAD occlusion with reperfusion did not alter % delta CVR in the vehicle group (36 +/- 6% versus 37 +/- 7%, P = NS) but attenuated % delta CVR in the anti-NGF group (39 +/- 8% to 17 +/- 2%, P < .05).

CONCLUSIONS: We conclude that exogenously infused and endogenously released NGF protects against postischemic neural stunning of sympathetic cardiac innervation.

Author List

Abe T, Morgan DA, Gutterman DD

MESH terms used to index this publication - Major topics in bold

Animals
Antibodies
Dogs
Female
Heart
Male
Myocardial Stunning
Nerve Growth Factors
Sympathetic Nervous System