Evaluation of continuous-infusion gallium nitrate and hydroxyurea in combination for the treatment of refractory non-Hodgkin's lymphoma. Am J Clin Oncol 1997 Apr;20(2):173-8
Date
04/01/1997Pubmed ID
9124195DOI
10.1097/00000421-199704000-00015Scopus ID
2-s2.0-0030947983 (requires institutional sign-in at Scopus site) 37 CitationsAbstract
Based on preclinical studies demonstrating synergy between gallium and hydroxyurea, we evaluated the efficacy and toxicity of continuous intravenous gallium nitrate in combination with oral hydroxyurea in patients with refractory non-Hodgkin's lymphoma. Fourteen patients, median age 64 years (range 53-89), with stage III or IV low- or intermediate-grade lymphoma were treated with gallium nitrate and hydroxyurea in combination for 7 days at four different dose levels: (a) gallium nitrate, 200 mg/m2/day; hydroxyurea, 500 mg/day; (b) gallium nitrate, 250 mg/m2/day; hydroxyurea, 1,000 mg/day; (c) gallium nitrate, 300 mg/m2/day; hydroxyurea, 1,000 mg/day; and (d) gallium nitrate, 350 mg/m2/day, hydroxyurea, 1,000 mg/day. All patients had progressive disease and had been heavily pretreated. Six of 14 patients had objective tumor regression following treatment (one complete response, one near-complete response, and four partial responses) with a median duration of response of 7 weeks (range 3-38 weeks). An additional four patients had minor responses. Responses occurred at all dose levels and in both low- and intermediate-grade histologic subtypes. The predominant toxicities encountered were anemia and reversible nephrotoxicity. Combination gallium nitrate and hydroxyurea has significant activity in lymphoma and is well tolerated even by elderly patients. Because of the lack of cross-resistance to other drugs and the potential synergistic antineoplastic activity, gallium nitrate and hydroxyurea should be further evaluated in combination with other chemotherapeutic agents.
Author List
Chitambar CR, Zahir SA, Ritch PS, Anderson TMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Evaluation Studies as Topic
Female
Gallium
Humans
Hydroxyurea
Infusions, Intravenous
Lymphoma, Non-Hodgkin
Male
Middle Aged
Nucleic Acid Synthesis Inhibitors
Tomography, X-Ray Computed
Treatment Outcome
