Integrating bioethics into clinical and translational science research: a roadmap. Clin Transl Sci 2008 May;1(1):67-70
Date
05/01/2008Pubmed ID
20443821Pubmed Central ID
PMC5439590DOI
10.1111/j.1752-8062.2008.00005.xScopus ID
2-s2.0-77953369492 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Recent initiatives to improve human health emphasize the need to effectively and appropriately translate new knowledge gleaned from basic biomedical and behavioral research to clinical and community application. To maximize the beneficial impact of scientific advances in clinical practice and community health, and to guard against potential deleterious medical and societal consequences of such advances, incorporation of bioethics at each stage of clinical and translational science research is essential. At the earliest stage, bioethics input is critical to address issues such as whether to limit certain areas of scientific inquiry. Subsequently, bioethics input is important to assure not only that human subjects trials are conducted and reported responsibly, but also that results are incorporated into clinical and community practices in a way that promotes and protects bioethical principles. At the final stage of clinical and translational science research, bioethics helps to identify the need and approach for refining clinical practices when safety or other concerns arise. The framework we present depicts how bioethics interfaces with each stage of clinical and translational science research, and suggests an important research agenda for systematically and comprehensively assuring bioethics input into clinical and translational science initiatives.
Author List
Shapiro RS, Layde PMMESH terms used to index this publication - Major topics in bold
BioethicsClinical Medicine
Clinical Trials as Topic
Cloning, Molecular
Cloning, Organism
Ethics, Research
Genetic Testing
Hemoglobins
Humans
Isotretinoin
