Antithyroid drugs and radioactive iodine. Fifteen years' experience with Graves' disease. Arch Intern Med 1979 Jun;139(6):651-3
Date
06/01/1979Pubmed ID
87156Scopus ID
2-s2.0-0018636498 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
The population for this study included 186 patients who were treated between 1962 and 1977 for diffuse toxic goiter. Patients were divided into two groups according to the primary mode of therapy, which was either thioamides or sodium iodide I 131. Of 96 patients who were treated with primary drug therapy, only 16% experienced a prolonged remission (more than two years) of hyperthyroidism. Except for a greater likelihood of remission among patients with mild hyperthyroidism, no other clinical features of Graves' disease were predictive of the long-term response to drug therapy. Among the 90 patients who received primary sodium iodide I 131 therapy, those who were pretreated with thioamides required a higher total dose to achieve a cure (13.8 mCi vs 9.6 mCi) and had a lower initial incidence of hypothyroidism (54% vs 73%).
Author List
Reynolds LR, Kotchen TAMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Antithyroid Agents
Child
Female
Graves Disease
Humans
Iodine Radioisotopes
Male
Middle Aged
Remission, Spontaneous
Thioamides
