Radiation-associated kidney injury. Int J Radiat Oncol Biol Phys 2010 Mar 01;76(3 Suppl):S108-15
Date
03/05/2010Pubmed ID
20171504DOI
10.1016/j.ijrobp.2009.02.089Scopus ID
2-s2.0-76449087155 (requires institutional sign-in at Scopus site) 253 CitationsAbstract
The kidneys are the dose-limiting organs for radiotherapy to upper abdominal cancers and during total body irradiation. The incidence of radiotherapy-associated kidney injury is likely underreported owing to its long latency and because the toxicity is often attributed to more common causes of kidney injury. The pathophysiology of radiation injury is poorly understood. Its presentation can be acute and irreversible or subtle, with a gradual progressive dysfunction over years. A variety of dose and volume parameters have been associated with renal toxicity and are reviewed to provide treatment guidelines. The available predictive models are suboptimal and require validation. Mitigation of radiation nephropathy with angiotensin-converting enzyme inhibitors and other compounds has been shown in animal models and, more recently, in patients.
Author List
Dawson LA, Kavanagh BD, Paulino AC, Das SK, Miften M, Li XA, Pan C, Ten Haken RK, Schultheiss TEMESH terms used to index this publication - Major topics in bold
AnimalsDose-Response Relationship, Radiation
Forecasting
Humans
Kidney
Models, Animal
Radiation Injuries
Radiation Tolerance
Whole-Body Irradiation
