Faculty Collaboration Database

Effects of the optical isomers of verapamil on electrophysiological properties of the heart in conscious dogs. Eur J Pharmacol 1998 Aug 21;355(2-3):159-66

Date

10/06/1998

Pubmed ID

9760030

DOI

10.1016/s0014-2999(98)00480-4

Scopus ID

2-s2.0-0031692911 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

We compared the cumulative dose-response relations of verapamil (0.1, 0.2 and 0.4 mg kg(-1)) in different R/S enantiomer ratios (100/0, 90/10, 80/20, 50/50 and 20/80) on the electrophysiological and hemodynamic characteristics of the heart using the conscious dogs. A reduction of mean arterial pressure occurred with 20R/80S producing a 3-times greater decrease than 100R/0S, but an increase in heart rate occurred with 20R/80S producing a 9-times greater increase than 100R/0S. Increased heart rate was concurrent with decreased mean arterial pressure most prevalent with a higher ratio of S-isomer that produced a greater reduction in mean arterial pressure and increase in heart rate at lower overall verapamil doses. Atrio-ventricular conduction time increased 3-5 min after each infusion, with 20R/80S producing a 4-times greater effect than 100R/0S. These results indicate that the peripheral and cardiac electrophysiologic properties of various nonracemic verapamil mixtures are mainly attributable to the concentration of S-isomer.

Author List

Takahata O, Krolikowski JG, McCallum JB, Lathrop DA, Bosnjak ZJ

Author

Zeljko Bosnjak PhD, MS Emeritus Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Anti-Arrhythmia Agents
Blood Pressure
Calcium Channel Blockers
Dogs
Female
Heart
Heart Conduction System
Heart Rate
Male
Stereoisomerism
Vasodilator Agents
Verapamil