Faculty Collaboration Database

Effects of the optical isomers of verapamil on electrophysiological properties of the heart in conscious dogs. Eur J Pharmacol 1998 Aug 21;355(2-3):159-66

Date

10/06/1998

Pubmed ID

9760030

DOI

10.1016/s0014-2999(98)00480-4

Scopus ID

2-s2.0-0031692911 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

We compared the cumulative dose-response relations of verapamil (0.1, 0.2 and 0.4 mg kg(-1)) in different R/S enantiomer ratios (100/0, 90/10, 80/20, 50/50 and 20/80) on the electrophysiological and hemodynamic characteristics of the heart using the conscious dogs. A reduction of mean arterial pressure occurred with 20R/80S producing a 3-times greater decrease than 100R/0S, but an increase in heart rate occurred with 20R/80S producing a 9-times greater increase than 100R/0S. Increased heart rate was concurrent with decreased mean arterial pressure most prevalent with a higher ratio of S-isomer that produced a greater reduction in mean arterial pressure and increase in heart rate at lower overall verapamil doses. Atrio-ventricular conduction time increased 3-5 min after each infusion, with 20R/80S producing a 4-times greater effect than 100R/0S. These results indicate that the peripheral and cardiac electrophysiologic properties of various nonracemic verapamil mixtures are mainly attributable to the concentration of S-isomer.

Author List

Takahata O, Krolikowski JG, McCallum JB, Lathrop DA, Bosnjak ZJ

MESH terms used to index this publication - Major topics in bold

Animals
Anti-Arrhythmia Agents
Blood Pressure
Calcium Channel Blockers
Dogs
Female
Heart
Heart Conduction System
Heart Rate
Male
Stereoisomerism
Vasodilator Agents
Verapamil