Faculty Collaboration Database

Serum nucleotide pyrophosphohydrolase activity; elevated levels in osteoarthritis, calcium pyrophosphate crystal deposition disease, scleroderma, and fibromyalgia. J Rheumatol 1998 Nov;25(11):2175-80

Date

11/18/1998

Pubmed ID

9818661

Scopus ID

2-s2.0-0031762714 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

OBJECTIVE: Quantification of serum nucleotide pyrophosphohydrolase (NTPPHase) activity in healthy subjects and in patients with various rheumatic diseases or with quad/hemiplegia, hemodialysis, or renal transplant.

METHODS: Colorimetric assay of enzyme activity in serum.

RESULTS: Serum NTPPHase activity in 85 healthy subjects was independent of age or sex and was highly reproducible in each individual. The biologic and methodologic coefficients of variation were nearly identical. Elevated enzyme levels were found in sera from patients with osteoarthritis/spondylosis, calcium pyrophosphate dihydrate (CPPD) crystal deposition, scleroderma, fibromyalgia, or hemodialysis. Renal transplant patients receiving cyclosporine had the highest enzyme activity of any group, whereas transplant patients not taking this drug had normal levels. Histograms of values in all groups showed a normal distribution.

CONCLUSION: Serum NTPPHase activity levels were significantly elevated in patients with degenerative arthritis whether or not CPPD crystals were present, in patients with either scleroderma or fibromyalgia, and in patients receiving hemodialysis therapy or taking cyclosporine.

Author List

Cardenal A, Masuda I, Ono W, Haas AL, Ryan LM, Trotter D, McCarty DJ

MESH terms used to index this publication - Major topics in bold

Chondrocalcinosis
Cyclosporine
Female
Fibromyalgia
Humans
Kidney Transplantation
Male
Osteoarthritis
Postoperative Care
Pyrophosphatases
Reference Values
Renal Dialysis
Scleroderma, Systemic