Faculty Collaboration Database

Identifying physiological origins of baroreflex dysfunction in salt-sensitive hypertension in the Dahl SS rat. Physiol Genomics 2010 Jun;42(1):23-41

Date

04/01/2010

Pubmed ID

20354102

Pubmed Central ID

PMC2888563

DOI

10.1152/physiolgenomics.00027.2010

Scopus ID

2-s2.0-77953223380 (requires institutional sign-in at Scopus site)   48 Citations

Abstract

Salt-sensitive hypertension is known to be associated with dysfunction of the baroreflex control system in the Dahl salt-sensitive (SS) rat. However, neither the physiological mechanisms nor the genomic regions underlying the baroreflex dysfunction seen in this rat model are definitively known. Here, we have adopted a mathematical modeling approach to investigate the physiological and genetic origins of baroreflex dysfunction in the Dahl SS rat. We have developed a computational model of the overall baroreflex heart rate control system based on known physiological mechanisms to analyze telemetry-based blood pressure and heart rate data from two genetic strains of rat, the SS and consomic SS.13(BN), on low- and high-salt diets. With this approach, physiological parameters are estimated, unmeasured physiological variables related to the baroreflex control system are predicted, and differences in these quantities between the two strains of rat on low- and high-salt diets are detected. Specific findings include: a significant selective impairment in sympathetic gain with high-salt diet in SS rats and a protection from this impairment in SS.13(BN) rats, elevated sympathetic and parasympathetic offsets with high-salt diet in both strains, and an elevated sympathetic tone with high-salt diet in SS but not SS.13(BN) rats. In conclusion, we have associated several important physiological parameters of the baroreflex control system with chromosome 13 and have begun to identify possible physiological mechanisms underlying baroreflex impairment and hypertension in the Dahl SS rat that may be further explored in future experimental and modeling-based investigation.

Author List

Bugenhagen SM, Cowley AW Jr, Beard DA

Author

Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Algorithms
Animals
Baroreflex
Central Nervous System
Chromosome Mapping
Computer Simulation
Heart Rate
Hypertension
Models, Biological
Peripheral Nervous System
Pressoreceptors
Rats
Rats, Inbred BN
Rats, Inbred Dahl
Sodium Chloride, Dietary
Species Specificity