Genetic mapping and chromosome localization of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene, a candidate for non-insulin-dependent diabetes mellitus. Genomics 1996 Nov 15;38(1):96-9
Date
11/15/1996Pubmed ID
8954787DOI
10.1006/geno.1996.0599Scopus ID
2-s2.0-0030588659 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase (mtGPD) plays an important role in the regulation of insulin secretion and has been postulated as a candidate responsible for the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) in humans as well as in rodent models of NIDDM. Recent molecular genetic studies of the Goto-Kakizaki (GK) rat model of NIDDM have identified loci linked to NIDDM. To elucidate whether rat mtGPD might play a role in the pathogenesis of NIDDM, the rat mtGPD gene (Gpd2) was cloned, and a genetic marker for Gpd2 was developed. The gene mapped to the region of rat chromosome 3 that contains a region linked to NIDDM in the GK rat. Fluorescence in situ hybridization was also carried out to verify the map position.
Author List
Koike G, Van Vooren P, Shiozawa M, Galli J, Li LS, Glaser A, Balasubramanyam A, Brown LJ, Luthman H, Szpirer C, MacDonald MJ, Jacob HJMESH terms used to index this publication - Major topics in bold
AnimalsChromosome Mapping
Cloning, Molecular
Diabetes Mellitus, Type 2
Disease Models, Animal
Genetic Linkage
Glycerolphosphate Dehydrogenase
Humans
In Situ Hybridization, Fluorescence
Mitochondria
Molecular Sequence Data
Rats
Restriction Mapping
