Faculty Collaboration Database

Actions of isoflurane on myocardial perfusion in chronically instrumented dogs with poor, moderate, or well-developed coronary collaterals. J Cardiothorac Anesth 1990 Dec;4(6):715-25

Date

12/01/1990

Pubmed ID

2131901

DOI

10.1016/s0888-6296(09)90010-2

Scopus ID

2-s2.0-0025601431 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

The influence of isoflurane on myocardial perfusion (determined by the radioactive microsphere technique) in normal regions and areas distal to a left anterior descending (LAD) coronary artery occlusion was evaluated in dogs that were chronically instrumented for measurement of systemic and coronary hemodynamics and had varying degrees of coronary collateral development. In 17 dogs, an Ameroid constrictor was implanted on the LAD coronary artery to produce a slowly progressive occlusion that stimulated development of the collateral circulation. Collateralization was allowed to progress in three groups of dogs to a poor (3 +/- 1 days), moderate (19 +/- 4 days), or well-developed (50 days) stage postsurgery. After the indicated period of time had elapsed, the LAD coronary artery was occluded (via Ameroid constrictor and/or balloon cuff occluder). Radioactive microspheres were administered during the conscious state and at 2% and 3% inspired concentrations of isoflurane. A fourth set of microspheres was injected at 3% isoflurane with heart rate and blood pressure adjusted to conscious levels. Isoflurane produced equivalent changes in systemic hemodynamics in all groups, including an increase in heart rate and decreases in arterial pressure and left ventricular peak positive dP/dt. Regional contractile function of normal myocardium was reduced by isoflurane in all groups. Isoflurane (3%) significantly decreased subepicardial, subendocardial, and transmural blood flow in normal and collateral-dependent regions in all groups. Myocardial perfusion returned to levels present in the conscious state when arterial pressure and heart rate were adjusted to those levels present prior to induction of anesthesia. Neither the left ventricular transmural distribution nor the collateral-dependent to normal zone flow ratio was altered from conscious levels by isoflurane in any group with or without changes in blood pressure and heart rate. The results indicate that isoflurane does not redistribute coronary blood flow from collateral-dependent to normal regions in a single-vessel coronary artery disease model. The actions of isoflurane are also independent of the degree of coronary collateral development.

Author List

Hartman JC, Kampine JP, Schmeling WT, Warltier DC

MESH terms used to index this publication - Major topics in bold

Anesthesia, Inhalation
Animals
Blood Flow Velocity
Blood Pressure
Cardiac Output
Catheterization
Collateral Circulation
Consciousness
Coronary Circulation
Coronary Disease
Dogs
Female
Heart Rate
Isoflurane
Male
Myocardial Contraction
Oxygen
Time Factors
Ventricular Function, Left