Faculty Collaboration Database

The effects of the new antiarrhythmic E 047/1 on postoperative ischemia-induced arrhythmias in dogs. Anesth Analg 1999 Dec;89(6):1393-9

Date

12/10/1999

Pubmed ID

10589614

DOI

10.1097/00000539-199912000-00012

Scopus ID

2-s2.0-0032747218 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

UNLABELLED: Perioperative malignant ventricular tachyarrhythmias pose an imminent clinical danger by potentially precipitating myocardial ischemia and severely compromising hemodynamics. Thus, immediate and effective therapy is required, which is not always provided by currently recommended IV drug regimens, indicating a need for more effective drugs. We examined antiarrhythmic effects of the new benzofurane compound E 047/1 on spontaneous ventricular tachyarrhythmia in a conscious dog model. One day after experimental myocardial infarction, 40 dogs exhibiting tachyarrhythmia randomly received (bolus plus 1-h infusion) E 047/1 6 mg/kg plus 6 mg x kg(-1) x h(-1), lidocaine 1 mg/kg plus 4.8 mg x kg(-1) x h(-1), flecainide 1 mg/kg plus 0.05 mg x kg(-1) x h(-1), amiodarone 10 mg/kg plus 1.8 mg x kg(-1) x h(-1), or bretylium 10 mg/kg plus 20 mg x kg(-1) x h(-1). Electrocardiogram was evaluated for number of premature ventricular contractions (PVC), normally conducted beats originating from the sinoatrial node, and episodes of ventricular tachycardia. Immediately after the bolus, E 047/1 reduced PVCs by 46% and increased sinoatrial beats from 4 to 61 bpm. The ratio of PVCs to total beats decreased from 98% to 58%. Amiodarone and flecainide exhibited antiarrhythmic effects with delayed onset. Lidocaine did not suppress PVCs significantly, and bretylium was proarrhythmic. The antiarrhythmic E 047/1 has desirable features, suppressing ischemia-induced ventricular tachyarrhythmia quickly and efficiently, and may be a useful addition to current therapeutic regimens.

IMPLICATIONS: Life-threatening arrhythmias of the heart after myocardial infarction or ischemia may be treated quickly and efficiently by the new drug E 047/1.

Author List

Kulier AH, Novalija E, Hogan Q, Vicenzi MN, Woehlck HJ, Bajic J, Atlee JL 3rd, Bosnjak ZJ

Authors

Jurica Bajic MD, PhD Assistant Professor in the Anesthesiology department at Medical College of Wisconsin
Harvey J. Woehlck MD Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Anti-Arrhythmia Agents
Arrhythmias, Cardiac
Benzofurans
Blood Pressure
Body Weight
Coronary Vessels
Dogs
Excipients
Heart Rate
Infusions, Intravenous
Ligation
Myocardial Ischemia
Pilot Projects
Polysorbates