Faculty Collaboration Database

Comparative relaxant effects of nitroglycerin in isolated rings from various canine vascular beds. Gen Pharmacol 1984;15(3):217-21

Date

01/01/1984

Pubmed ID

6428967

DOI

10.1016/0306-3623(84)90162-9

Scopus ID

2-s2.0-0021265578 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

The potency of nitroglycerin to block contractions produced by norepinephrine, serotonin and KCl, was examined in isolated large artery rings obtained from the coronary, femoral, mesenteric and renal vascular bed of the dog. Nitroglycerin was a more potent antagonist (10-10,000 fold) of contractions produced by norepinephrine in the large coronary artery than in the other three vascular beds. Similarly, nitroglycerin blocked responses to serotonin and KCl (40 mM) more effectively in the coronary vs the femoral artery. These results suggest that nitroglycerin has selectivity for the large coronary artery of the dog in blocking contractions produced by three constrictor substances that have been implicated in coronary vasospasm.

Author List

Gharaibeh MN, Gross GJ

MESH terms used to index this publication - Major topics in bold

Animals
Dogs
Female
Femoral Artery
In Vitro Techniques
Male
Mesenteric Arteries
Muscle Contraction
Muscle Relaxation
Muscle, Smooth, Vascular
Nitroglycerin
Norepinephrine
Potassium Chloride
Renal Artery
Serotonin Antagonists