Effect of molsidomine on coronary collateral blood flow in acute myocardial ischemia. Eur J Pharmacol 1980 Oct 03;67(1):111-4
Date
10/03/1980Pubmed ID
6893436DOI
10.1016/0014-2999(80)90016-3Scopus ID
2-s2.0-0018928854 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
The actions of molsidomine, a new antianginal agent, on coronary collateral blood flow and myocardial oxygen consumption were studied in anesthetized dogs with acute ligation of the distal third of the left anterior descending coronary artery. Molsidomine (50 and 100 microgram/kg, i.v.) produced a significant decrease in myocardial oxygen consumption, however no change occurred in collateral blood flow. These results suggest that the beneficial actions of molsidomine in myocardial ischemia are primarily due to a decrease in oxygen demand.
Author List
Gross GJ, Gharaibeh MMESH terms used to index this publication - Major topics in bold
AnimalsCoronary Circulation
Coronary Disease
Dogs
Female
Hemodynamics
Male
Molsidomine
Morpholines
Oxadiazoles
Oxygen Consumption
Sydnones
Vasodilator Agents
