Improvement in ischemic myocardial blood flow following a new calcium antagonist. Am J Physiol 1980 Aug;239(2):H163-71
Date
08/01/1980Pubmed ID
6773426DOI
10.1152/ajpheart.1980.239.2.H163Scopus ID
2-s2.0-17544402639 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
The effect of FR 7534, a new dihydropyridine CA2+ antagonist, nitroglycerin, and dipyridamole have been compared on coronary collateral function in pentobarbital-anesthetized open-chest dogs following acute ligation of the left anterior descending coronary artery. Measurements of tissue blood flow using radioactive microspheres were made 60 min postligation after low and high doses of each drug and at the higher dose with methoxamine added to to return mean aortic pressure. FR 7534 treatment increased subepicardial, subendocardial, and transmural tissue flow by 100% in the central ischemic zone when perfusion pressure was controlled by methoxamine. Nitroglycerin also increased ischemic tissue flow, but to a lesser degree, 18% transmurally. Dipyridamole produced no significant change. Tissue flow in normal myocardium was similarly increased by FR 7534 and dipyridamole but slightly reduced by nitroglycerin. FR 7534 and nitroglycerin also increased retrograde coronary pressure when aortic presure was maintained constant. FR 7534, but not nitroglycerin, increased ischemic contractile force. In this model, FR 7534 may produce greater effects than nitroglycerin in increasing blood supply to ischemic myocardium delivered by endogenous collaterals especially when aortic perfusion pressure was controlled.
Author List
Jolly SR, Gross GJMESH terms used to index this publication - Major topics in bold
AnimalsCalcium
Coronary Circulation
Dipyridamole
Dogs
Dose-Response Relationship, Drug
Female
Male
Microspheres
Myocardium
Nifedipine
Nitroglycerin
Oxygen Consumption
Perfusion
Pyridines
Regional Blood Flow
