Effect of FR 7534, a new calcium antagonist, on myocardial oxygen demand. Eur J Pharmacol 1979 Mar 01;54(3):289-93
Date
03/01/1979Pubmed ID
107031DOI
10.1016/0014-2999(79)90088-8Scopus ID
2-s2.0-0018716085 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
The actions of FR 7534, a new calcium antagonist, nitroglycerin, and dipyridamole on myocardial oxygen demand have been compared. Six anaesthetized dogs received two infusion levels of each drug which produced equivalent arterial hypotension. All three compounds reduced the tension-time index (TTI). FR 7534 and nitroglycerin but not dipyridamole produced significant decreases in myocardial oxygen consumption (MVO2). FR 7534 demonstrated oxygen-sparing actions comparable to nitroglycerin. FR 7534 may prove beneficial in alleviating myocardial ischemia.
Author List
Jolly SR, Gross GJMESH terms used to index this publication - Major topics in bold
AnimalsCalcium
Dipyridamole
Dogs
Female
Hemodynamics
Male
Myocardium
Nifedipine
Nitroglycerin
Oxygen
Oxygen Consumption
Pyridines
