Effect of propranolol and nitroglycerin plus methoxamine on transmural creatine kinase activity after acute coronary occlusion. Am J Cardiol 1978 Nov;42(5):769-73
Date
11/01/1978Pubmed ID
101067DOI
10.1016/0002-9149(78)90096-6Scopus ID
2-s2.0-0018083778 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
Transmural creatine kinase activity was determined 5 hours after acute occlusion of the left anterior descending coronary artery in 27 open chest anesthetized dogs. In seven dogs, propranolol, 2 mg/kg, was given intravenously over a 10 minute period 10 minutes after occlusion. In 10 dogs, nitroglycerin, 300 microgram/min, was infused intravenously for 1 hour 10 minutes after occlusion. Methoxamine, 300 to 500 microgram, was administered to return blood pressure and heart rate to prenitroglycerin levels. In untreated dogs, there was a distinct transmural gradient of creatine kinase activity in the ischemic region from subepicardium to subendocardium: nonischemic subepicardium 1,187 +/- 50 international units (IU)/g versus ischemic subepicardium 1,054 +/- 46 IU/g and nonischemic subendocardium 1,170 +/- 53 IU/g versus ischemic subendocard;um 766 +/- 42 IU/g, respectively. Administration of propranolol did not affect the transmural creatine kinase gradient after 5 hours of occlusion. In contrast, nitroglycerin plus methoxamine significantly (P less than 0.05) decreased subendocardial creatine kinase depletion after 5 hours of occlusion (776 +/- 42 versus 978 +/- 47 IU/g). These findings demonstrate the unique capability of nitroglycerin plus methoxamine to protect the subendocardium during ischemic insult.
Author List
Jesmok GJ, Gross GJ, Hardman HFMESH terms used to index this publication - Major topics in bold
Acute DiseaseAnimals
Creatine Kinase
Dogs
Drug Evaluation, Preclinical
Female
Hemodynamics
Infusions, Parenteral
Injections, Intravenous
Male
Methoxamine
Myocardial Infarction
Myocardium
Nitroglycerin
Propranolol
Time Factors
