Successful brief captopril treatment in experimental radiation nephropathy. J Lab Clin Med 1997 May;129(5):536-47
Date
05/01/1997Pubmed ID
9142050DOI
10.1016/s0022-2143(97)90008-1Scopus ID
2-s2.0-0031147998 (requires institutional sign-in at Scopus site) 42 CitationsAbstract
Experimental renal irradiation is followed by a well-defined sequence of events leading to kidney failure. Inhibitors of angiotensin-converting enzyme can prevent the structural and functional changes that occur after renal irradiation, which suggests that the renin-angiotensin system plays a key role in their evolution. We therefore evaluated captopril, used for short intervals, in a total body irradiation model of radiation nephropathy. Irradiated 7- to 8-week-old rats that were treated with captopril from 3.5 to 9.5 weeks after irradiation had better kidney function and survival than irradiated animals treated at earlier or later intervals. At 26 weeks after irradiation, kidney function of these animals was similar to that of irradiated animals treated continuously with captopril, but their subsequent survival was less. Animals irradiated at 7 to 8 weeks of age and treated with captopril from 6 to 9 weeks after irradiation had better function and survival than animals treated at earlier or later intervals. Irradiated 15-week-old animals had significant functional and survival benefit from continuous captopril treatment but no protection from a 6-week interval of therapy. We conclude that radiation nephropathy may be significantly attenuated by the use of captopril from 3.5 to 9.5 weeks after irradiation in young animals. Although older animals did not appear to benefit from a short course of captopril, these data suggest that the renin-angiotensin system is important in the sequential expression of renal radiation injury, particularly between 3.5 and 9.5 weeks after irradiation.
Author List
Cohen EP, Fish BL, Moulder JEMESH terms used to index this publication - Major topics in bold
Angiotensin-Converting Enzyme InhibitorsAnimals
Bone Marrow Transplantation
Captopril
Kidney
Kidney Diseases
Kidney Function Tests
Nephritis
Radiation Injuries, Experimental
Radiation-Protective Agents
Rats
Specific Pathogen-Free Organisms
Survival Rate
Whole-Body Irradiation
