Functional MRI evidence for subcortical participation in conceptual reasoning skills. Neuroreport 1997 May 27;8(8):1987-93
Date
05/27/1997Pubmed ID
9223090DOI
10.1097/00001756-199705260-00038Scopus ID
2-s2.0-0030797422 (requires institutional sign-in at Scopus site) 120 CitationsAbstract
Lesions involving the dorsolateral prefrontal lobes may produce deficits on conceptual reasoning (CR) tasks in humans. Such deficits can also occur with subcortical lesions involving the basal ganglia, thalamus, or cerebellum, suggesting a common, yet widespread, neural network supporting this executive function. Here we report the results of a whole brain functional magnetic resonance imaging (fMRI) experiment in healthy volunteers while performing a CR task. Compared to a sensorimotor control condition, the CR task resulted in discrete subcortical activation sites primarily involving the right basal ganglia, right thalamus and left lateral cerebellum. Cortical activation was present in multiple systems, including the dorsolateral prefrontal and inferior frontal/insular areas; posterior parietal, superior extrastriate, and premotor areas; inferior extrastriate and middle temporal regions; and midline pre-supplementary motor and anterior cingulate regions. Our findings provide strong evidence that CR is mediated by interacting neural systems involving the cerebral cortex, basal ganglia, thalamus, and cerebellum.
Author List
Rao SM, Bobholz JA, Hammeke TA, Rosen AC, Woodley SJ, Cunningham JM, Cox RW, Stein EA, Binder JRAuthor
Jeffrey R. Binder MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultBasal Ganglia
Brain
Cerebellum
Concept Formation
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Thalamus
